The tumour microenvironment is the primary location in which tumour cells and the host
immune system interact. Different immune cell subsets are recruited into the tumour …

Despite the abundant ongoing research efforts, cancer remains one of the most challenging
diseases to treat globally. Due to the heterogenous nature of cancer, one of the major …

Cancer stem cells (CSCs), also known as tumor‐initiating cells (TICs), are elucidated as
cells that can perpetuate themselves via autorestoration. These cells are highly resistant to …

Four main histological subtypes of ovarian cancer exist: serous (the most frequent),
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …

Ovarian carcinomas relate to highest death rate in gynecologic malignancies as absence of
symptoms shield the disease in the early stage. Current evidences have been devoted to …

Ovarian cancer is most deadly gynecologic malignancies worldwide. Chemotherapy is the
mainstay treatment for ovarian cancer. Despite the initial response is promising, frequent …

Ability to form cellular aggregations such as tumorspheres and spheroids have been used
as a morphological marker of malignant cancer cells and in particular cancer stem cells …

The cancer stem cell (CSC) model proposes that tumor development and progression are
fueled and sustained by undifferentiated cancer cells, endowed with self-renewal and tumor …

Advances in cancer research in the past have led to an evolving understanding of cancer
pathogenesis and the development of novel drugs that significantly improve patient …

Simple Summary SOX2, OCT4, and NANOG are enriched in ovarian cancer spheroids and
correlate with tumor-initiating cell markers, CD117 and ALDH/CD133. SOX2, relative to …