[HTML][HTML] C6 cell line: The gold standard in glioma research
D Giakoumettis, A Kritis, N Foroglou - Hippokratia, 2018 - ncbi.nlm.nih.gov
Background: Glioblastoma multiforme is the most aggressive brain tumor with poor
prognosis and an average survival of 1-2 years. Animal models that simulate the features of …
prognosis and an average survival of 1-2 years. Animal models that simulate the features of …
[HTML][HTML] Magnetic resonance spectroscopy—revisiting the biochemical and molecular milieu of brain tumors
Background Magnetic resonance spectroscopy (MRS) is an established tool for in-vivo
evaluation of the biochemical basis of human diseases. On one hand, such lucid depiction …
evaluation of the biochemical basis of human diseases. On one hand, such lucid depiction …
The GABA and GABA-receptor system in inflammation, anti-tumor immune responses, and COVID-19
J Tian, DL Kaufman - Biomedicines, 2023 - mdpi.com
GABA and GABAA-receptors (GABAA-Rs) play major roles in neurodevelopment and
neurotransmission in the central nervous system (CNS). There has been a growing …
neurotransmission in the central nervous system (CNS). There has been a growing …
MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound
Systemically administered chemotherapeutic drugs are often ineffective in the treatment of
invasive brain tumors due to poor therapeutic index. Within gliomas, despite the presence of …
invasive brain tumors due to poor therapeutic index. Within gliomas, despite the presence of …
[HTML][HTML] M2 macrophages are more resistant than M1 macrophages following radiation therapy in the context of glioblastoma
MM Leblond, EA Pérès, C Helaine, AN Gérault… - Oncotarget, 2017 - ncbi.nlm.nih.gov
In some highly inflammatory tumors, such as glioblastoma (GB), macrophages (MΦ)
represent the most abundant population of reactive cells. MΦ, initially denoted as M0 MΦ …
represent the most abundant population of reactive cells. MΦ, initially denoted as M0 MΦ …
Proton magnetic resonance spectroscopy lactate/N-acetylaspartate within 2 weeks of birth accurately predicts 2-year motor, cognitive and language outcomes in …
S Mitra, GS Kendall, A Bainbridge, M Sokolska… - Archives of Disease in …, 2019 - fn.bmj.com
Objective Brain proton (1 H) magnetic resonance spectroscopy (MRS) lactate/N-
acetylaspartate (Lac/NAA) peak area ratio is used for prognostication in neonatal …
acetylaspartate (Lac/NAA) peak area ratio is used for prognostication in neonatal …
Imaging the intratumoral–peritumoral extracellular pH gradient of gliomas
Solid tumors have an acidic extracellular pH (pHe) but near neutral intracellular pH (pHi).
Because acidic pHe milieu is conducive to tumor growth and builds resistance to therapy …
Because acidic pHe milieu is conducive to tumor growth and builds resistance to therapy …
The role of astrocytes in CNS tumors: pre-clinical models and novel imaging approaches
Brain metastasis is a significant clinical problem, yet the mechanisms governing tumor cell
extravasation across the blood-brain barrier (BBB) and CNS colonization are unclear …
extravasation across the blood-brain barrier (BBB) and CNS colonization are unclear …
Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized 13C magnetic resonance spectroscopic imaging
JM Park, LD Recht, S Josan, M Merchant… - Neuro …, 2013 - academic.oup.com
Background The metabolic phenotype that derives disproportionate energy via glycolysis in
solid tumors, including glioma, leads to elevated lactate labeling in metabolic imaging using …
solid tumors, including glioma, leads to elevated lactate labeling in metabolic imaging using …
Imaging hallmarks of the tumor microenvironment in glioblastoma progression
Glioblastoma progression involves multifaceted changes in vascularity, cellularity, and
metabolism. Capturing such complexities of the tumor niche, from the tumor core to the …
metabolism. Capturing such complexities of the tumor niche, from the tumor core to the …