Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …

Neurons are among the most compartmentalized and interactive of all cell types. Like all
cells, neurons use proteins as the main sensors and effectors. The modification of the …

Axons extend for tremendously long distances from the neuronal soma and make use of
localized mRNA translation to rapidly respond to different extracellular stimuli and …

Neurons decentralize protein synthesis from the cell body to support the active metabolism
of remote dendritic and axonal compartments. The neuronal RNA transport apparatus …

Owing to their morphological complexity and dense network connections, neurons modify
their proteomes locally, using mRNAs and ribosomes present in the neuropil (tissue …

As our understanding of the cell interior has grown, we have come to appreciate that most
cellular operations are localized, that is, they occur at discrete and identifiable locations or …

Cells adopt highly polarized shapes and form distinct subcellular compartments in many
cases due to the localization of many mRNAs to specific areas, where they are translated …

The ribosome is an ancient molecular fossil that provides a telescope to the origins of life.
Made from RNA and protein, the ribosome translates mRNA to coded protein in all living …

Neurons use local protein synthesis to support their morphological complexity, which
requires independent control across multiple subcellular compartments up to the level of …

Localized mRNA translation regulates synapse function and axon maintenance, but how
compartment-specific mRNA repertoires are regulated is largely unknown. We developed an …