Abstract Different multicomponent 1, 3-dipolar cycloadditions (1, 3-DC) of cyclic α-amino
acid derivatives with aldehydes and dipolarophiles have been described as efficient and …

The reaction with β-trifluoromethyl acrylamide 3e and azomethine ylides generated from l-
proline and several aldehydes provided the corresponding trifluoromethylated pyrrolizidines …

Depsipeptides are biologically active peptide derivatives that possess a high therapeutic
interest. The development of depsipeptide mimics characterized by a chemical diversity …

A general synthesis of highly substituted pyrrolizidines can be performed by a
multicomponent 1, 3-dipolar cycloaddition using proline ester hydrochlorides, aldehydes …

Diastereoselective multicomponent reactions of enantioenriched 4-nitroprolinates, obtained
by enantiocatalyzed 1, 3-dipolar cycloaddition (1, 3-DC) of imino esters and nitroalkenes …

Construction of spirocyclic pyrrolidines bearing a spiro quaternary stereocenter is an
enormous challenge in synthetic organic chemistry. In this report, we introduce a Ag …

A class of multifunctional amidophosphanes derived from chiral 1, 2-
diphenylethylenediamines and natural α-amino acids has been developed. Among these, in …

The first diastereoselective synthesis of spirothiooxindoles is reported via the Michael
reaction between thiooxindoles and dibenzalacetones. The reaction was conducted without …

Guanidine hydrochloride has been successfully used in one-pot three component assembly
of aromatic aldehyde, ethyl acetoacetate and ammonium acetate to produce 1, 4 …

An acid-mediated annulation reaction for the formation of 7a-substituted unnatural
pyrrolizidines is described. To reach this goal, the pyrroline 3-(3, 4-dihydro-2H-pyrrol-5-yl) …