Preeclampsia, a systemic vascular disorder characterized by new-onset hypertension and
proteinuria after 20 weeks of gestation, is the leading cause of maternal and perinatal …

Acute kidney injury (AKI) is a major kidney disease characterized by an abrupt loss of renal
function. Accumulating evidence indicates that incomplete or maladaptive repair after AKI …

Patients are exposed to numerous prescribed and over-the-counter medications.
Unfortunately, drugs remain a relatively common cause of acute and chronic kidney injury. A …

Thrombotic microangiopathy (TMA), a pathological lesion observed in a wide spectrum of
diseases, is triggered by endothelial injury and/or dysfunction. Although TMA lesions are …

Inhibition of vascular endothelial growth factor A (VEGFA)/vascular endothelial growth factor
receptor 2 (VEGFR2) signaling is a common therapeutic strategy in oncology, with new …

Age-related macular degeneration (AMD) is a disease that affects the macula–the central
part of the retina. It is a leading cause of irreversible vision loss in the elderly. AMD onset is …

The kidney is permeated by a highly complex vascular system with glomerular and
peritubular capillary networks that are essential for maintaining the normal functions of …

Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly
in the Western world. While AMD is a multifactorial disease, the complement system was …

The polarized phenotype of the retinal pigment epithelium is crucial for the outer retina-
blood barrier and support of photoreceptors and underlying choroid, and its disruption plays …

The complement system is crucial for immune surveillance, providing the body's first line of
defence against pathogens. However, an imbalance in its regulators can lead to …