Cells maintain intracellular pH (pHi) within a narrow range (7.1–7.2) by controlling
membrane proton pumps and transporters whose activity is set by intra-cytoplasmic pH …

Why do neurons sense extracellular acid? In large part, this question has driven increasing
investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Plasma membrane (PM) ion channels contribute to virtually all basic cellular processes and
are also involved in the malignant phenotype of cancer cells. Here, we review the role of ion …

The concentration of sodium ions (Na+) is raised in solid tumours and can be measured at
the cellular, tissue and patient levels. At the cellular level, the Na+ gradient across the …

Cancer accounts for 13% of the yearly total mortality worldwide. Most cancer deaths are the
sequel of metastatic diseases rather than of primary tumor growth. Thus, the major challenge …

Despite the multidisciplinary integration in the therapeutic management of glioblastoma
multiforme (GBM), the prognosis of GBM patients is poor. There is growing recognition that …

The nervous system spread of alpha-synuclein fibrils is thought to cause Parkinson's
disease (PD) and other synucleinopathies; however, the mechanisms underlying …

Malignant gliomas metastasize throughout the brain by infiltrative cell migration into
peritumoral areas. Invading cells undergo profound changes in cell shape and volume as …

Cell migration is a process that plays an important role throughout the entire life span. It
starts early on during embryogenesis and contributes to shaping our body. Migrating cells …