Publisher Summary As normal cells progress to tumorigenicity, they must develop two
distinct new characteristics not possessed by the normal cells from which they arise: they …

Angiogenesis, or new blood vessel formation, is now known to play an important role in both
growth and metastasis of many cancers. The central importance of angiogenesis and the …

Angiogenesis is a significant prognostic factor in breast cancer, but the factors that control
angiogenesis in vivo are not well defined. Multiple angiogenic polypeptides are known, and …

Endothelial cells constitute an essential integrator of factors that effect blood vessel
remodeling induced by chronic hypoxia. We hypothesized that vascular endothelial growth …

Inhibitors of tumor angiogenesis and metastasis are rapidly emerging as important new drug
candidates for cancer therapy. To facilitate the identification of such drugs, we recently …

PURPOSE To review prognostic and therapeutic applications of angiogenesis research in
breast carcinoma. METHODS We reviewed the (1) biologic role of angiogenesis, particularly …

Tumor development is angiogenesis dependent, and vascular endothelial growth factor
(VEGF) is a key growth factor in this process. We demonstrate that high expression of VEGF …

The remodelling of the extracellular matrix (ECM) has been shown to be highly upregulated
in cancer and inflammation and is critically linked to the processes of invasion and …

Angiogenesis is the development of new blood vessels from an existing vascular bed.
Normal vascular proliferation occurs only during embryonic development, the female …

This review summarizes a series of studies demonstrating that heparan sulfate
proteoglycans act to promote the growth and metastasis of myeloma and breast tumors, two …