The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …

Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in
antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent …

NOX2 is the prototypical member of the NADPH oxidase NOX superfamily and produces
superoxide (O2•−), a key reactive oxygen species (ROS) that is essential in innate and …

Nearly 130 years after the first insights into the existence of mitochondria, new
rolesassociated with these organelles continue to emerge. As essential hubs that dictate cell …

Staphylococcus aureus causes many types of human infections and syndromes—most
notably skin and soft tissue infections. Abscesses are a frequent manifestation of S. aureus …

Significance: When neutrophils kill microorganisms, they ingest them into phagosomes and
bombard them with a burst of reactive oxygen species. Recent Advances: This review …

Reactive oxygen species (ROS) are derivatives of molecular oxygen (O 2) involved in
various physiological and pathological processes. In immune cells, ROS are mediators of …

Staphylococcus aureus has been an important human pathogen throughout history and is
currently a leading cause of bacterial infections worldwide. S. aureus has the unique ability …

The phagocytic response of innate immune cells such as macrophages is defined by the
activation of complex signaling networks that are stimulated by microbial contact. Many …

Proton channels exist in a wide variety of membrane proteins where they transport protons
rapidly and efficiently. Usually the proton pathway is formed mainly by water molecules …