The extracellular matrix is an integral and dynamic component of all tissues.
Macromolecular compositions and structural architectures of the matrix are tissue-specific …

The main features of the triple helical structure of collagen were deduced in the mid-1950s
from fibre X-ray diffraction of tendons. Yet, the resulting models only could offer an average …

The molecular conformation of the collagen triple helix confers strict amino acid sequence
constraints, requiring a (Gly-XY) n repeating pattern and a high content of imino acids. The …

The collagen prolyl 4-hydroxylases (P4Hs), enzymes residing within the endoplasmic
reticulum, have a central role in the biosynthesis of collagens. In addition, cytoplasmic P4Hs …

The collagen superfamily is highly complex and shows a remarkable diversity in molecular
and supramolecular organization, tissue distribution and function. However, all its members …

Regenerative medicine strategies for restoring articular cartilage face significant challenges
to recreate the complex and dynamic biochemical and biomechanical functions of native …

An algorithm was derived to relate the amino acid sequence of a collagen triple helix to its
thermal stability. This calculation is based on the triple helical stabilization propensities of …

The ubiquitous fungal pathogen Metarhizium anisopliae kills a wide range of insects. Host
hemocytes can recognize and ingest its conidia, but this capacity is lost on production of …

Collagens are the most abundant proteins of the extracellular matrix, and the hierarchical
folding and supramolecular assembly of collagens into banded fibers is essential for …

In the growing field of tissue engineering, providing cells in biomaterials with the adequate
biological cues represents an increasingly important challenge. Yet, biomaterials with …