[HTML][HTML] Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2

P Han, L Li, S Liu, Q Wang, D Zhang, Z Xu, P Han, X Li… - Cell, 2022 - cell.com
Summary The coronavirus disease 2019 (COVID-19) pandemic continues worldwide with
many variants arising, some of which are variants of concern (VOCs). A recent VOC, omicron …

The NIH Comparative Genomics Resource: addressing the promises and challenges of comparative genomics on human health

K Bornstein, G Gryan, ES Chang, A Marchler-Bauer… - BMC genomics, 2023 - Springer
Comparative genomics is the comparison of genetic information within and across
organisms to understand the evolution, structure, and function of genes, proteins, and non …

Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants

Z Zhao, Y Xie, B Bai, C Luo, J Zhou, W Li… - Nature …, 2023 - nature.com
Abstract Multiple SARS-CoV-2 Omicron sub-variants, such as BA. 2, BA. 2.12. 1, BA. 4, and
BA. 5, emerge one after another. BA. 5 has become the dominant strain worldwide …

The next major emergent infectious disease: Reflections on vaccine emergency development strategies

Y Bai, Q Wang, M Liu, L Bian, J Liu, F Gao… - Expert review of …, 2022 - Taylor & Francis
Introduction Major emergent infectious diseases (MEID) pose the most serious threat to
human health. The research proposes targeted response strategies for the prevention and …

Binding and structural basis of equine ACE2 to RBDs from SARS-CoV, SARS-CoV-2 and related coronaviruses

Z Xu, X Kang, P Han, P Du, L Li, A Zheng… - Nature …, 2022 - nature.com
The origin and host range of SARS-CoV-2, the causative agent of coronavirus disease 2019
(COVID-19), are important scientific questions as they might provide insight into …

Broader-species receptor binding and structural bases of Omicron SARS-CoV-2 to both mouse and palm-civet ACE2s

L Li, P Han, B Huang, Y Xie, W Li, D Zhang, P Han… - Cell Discovery, 2022 - nature.com
The Omicron variant of SARS-CoV-2 carries multiple unusual mutations, particularly in the
receptor-binding domain (RBD) of the spike (S) protein. Moreover, host-adapting mutations …

Omicron variant of SARS-CoV-2 imposes a new challenge for the global public health

Z Xu, K Liu, FG George - Biosafety and Health, 2022 - mednexus.org
Since its first discovery, the Omicron variant of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has evoked another wave of infection and caused global …

Structural basis of white-tailed deer, Odocoileus virginianus, ACE2 recognizing all the SARS-CoV-2 variants of concern with high affinity

P Han, Y Meng, D Zhang, Z Xu, Z Li, X Pan… - Journal of …, 2023 - Am Soc Microbiol
ABSTRACT SARS-CoV-2 has been expanding its host range, among which the white-tailed
deer (WTD), Odocoileus virginianus, became the first wildlife species infected on a large …

Molecular basis of mink ACE2 binding to SARS-CoV-2 and its mink-derived variants

C Su, J He, P Han, B Bai, D Li, J Cao, M Tian… - Journal of …, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted between
humans and minks, and some mutations in the spike (S) protein, especially in the receptor …

Structural basis and analysis of hamster ACE2 binding to different SARS-CoV-2 spike RBDs

S Niu, Z Zhao, Z Liu, X Rong, Y Chai, B Bai… - Journal of …, 2024 - Am Soc Microbiol
Pet golden hamsters were first identified being infected with the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) delta variant of concern (VOC) and transmitted the …