Vitamin D plays a major role in the regulation of mineral homeostasis and affects bone
metabolism. Most effects of vitamin D have been attributed to the 1, 25-dihydroxyvitamin D3 …

Bone formation in vivo is a complex phenomenon whereby recruitment and replication of
mesenchymal precursors of osteoblasts, differentiation into preosteoblasts, osteoblasts, and …

Bone tissue arises from mesenchymal cells induced into the osteoblast lineage by essential
transcription factors and signaling cascades. MicroRNAs regulate biological processes by …

Zinc is an essential trace element required for bone formation, however not much has been
clarified yet for its role in osteoblast. We hypothesized that zinc would increase osteogenetic …

The success of an implant is determined by its integration into the tissue surrounding the
biomaterial. Surface roughness and composition are considered to influence the properties …

Tissue formation is determined by uncountable biochemical signals between cells; in
addition, physical parameters have been shown to exhibit significant effects on the level of …

Biomaterial surface chemistry has profound consequences on cellular and host responses,
but the underlying molecular mechanisms remain poorly understood. Using self-assembled …

Cells are known to sense and respond to the physical properties of their environment and
those of tissue scaffolds. Optimizing these cell–material interactions is critical in tissue …

Fabricating functionally graded scaffolds from biodegradable polymers to enable the
mimicking of native tissue is an important challenge. Here we demonstrate the fabrication …

Abstract Runx2 (Cbfa1, AML-3) is multifunctional transcription factor that is essential for
osteoblast development. Runx2 binds specific DNA sequences and interacts with …