Lysosomes are degradation centers and signaling hubs in cells and play important roles in
cellular homeostasis, development, and aging. Changes in lysosome function are essential …

Lysosomal storage diseases (LSDs) are a group of over 70 diseases that are characterized
by lysosomal dysfunction, most of which are inherited as autosomal recessive traits. These …

Lipids are abundant and play essential roles in human health and disease. The main
functions of lipids are building blocks for membrane biogenesis. However, lipids are also …

Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for
degradation. Here we consider its roles in neuronal health and disease. We review …

Lysosomal storage diseases are a group of metabolic disorders caused by deficiencies of
several components of lysosomal function. Most commonly affected are lysosomal …

The endoplasmic reticulum (ER) is the largest organelle in the cell, and its functions have
been studied for decades. The past several years have provided novel insights into the …

Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …

The lysosome has long been viewed as the recycling center of the cell. However, recent
discoveries have challenged this simple view and have established a central role of the …

Lysosomes are acidic compartments filled with more than 60 different types of hydrolases.
They mediate the degradation of extracellular particles from endocytosis and of intracellular …

For a long time, lysosomes were considered merely to be cellular'incinerators' involved in
the degradation and recycling of cellular waste. However, now there is compelling evidence …