Epidemiology of IgA nephropathy: a global perspective

FP Schena, I Nistor - Seminars in nephrology, 2018 - Elsevier
IgA nephropathy (IgAN), or Berger's disease, is the most common primary glomerular
disease worldwide, but varies largely in its geographic distribution. A systematic review of …

IgA nephropathy

KN Lai, SCW Tang, FP Schena, J Novak… - Nature reviews Disease …, 2016 - nature.com
Abstract Globally, IgA nephropathy (IgAN) is the most common primary glomerulonephritis
that can progress to renal failure. The exact pathogenesis of IgAN is not well defined, but …

[HTML][HTML] New developments in the genetics, pathogenesis, and therapy of IgA nephropathy

R Magistroni, VD D'Agati, GB Appel, K Kiryluk - Kidney international, 2015 - Elsevier
Recent years have brought notable progress in the field of IgA nephropathy. Here, we
highlight important new directions and latest developments, including successful discovery …

[HTML][HTML] Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis

K Kiryluk, Y Li, S Sanna-Cherchi… - PLoS …, 2012 - journals.plos.org
IgA nephropathy (IgAN), major cause of kidney failure worldwide, is common in Asians,
moderately prevalent in Europeans, and rare in Africans. It is not known if these differences …

[HTML][HTML] The emerging role of complement proteins as a target for therapy of IgA nephropathy

DV Rizk, N Maillard, BA Julian, B Knoppova… - Frontiers in …, 2019 - frontiersin.org
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide
and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is …

The role of complement in IgA nephropathy

A Tortajada, E Gutierrez, MC Pickering, MP Terente… - Molecular …, 2019 - Elsevier
IgA nephropathy (IgAN) is common and often progresses to end stage renal disease. IgAN
encompasses a wide range of histology and clinical features. IgAN pathogenesis is …

[HTML][HTML] The origin and activities of IgA1-containing immune complexes in IgA nephropathy

B Knoppova, C Reily, N Maillard, DV Rizk… - Frontiers in …, 2016 - frontiersin.org
IgA nephropathy (IgAN) is the most common primary glomerulonephritis, frequently leading
to end-stage renal disease, as there is no disease-specific therapy. IgAN is diagnosed from …

[HTML][HTML] Aberrant glycosylation of IgA1 is inherited in both pediatric IgA nephropathy and Henoch–Schönlein purpura nephritis

K Kiryluk, Z Moldoveanu, JT Sanders, TM Eison… - Kidney international, 2011 - Elsevier
Serum galactose-deficient immunoglobulin A1 (Gd-IgA1) is an inherited risk factor for adult
IgA nephropathy (IgAN). In this paper, we determined the heritability of serum Gd-IgA1 levels …

HLA has strongest association with IgA nephropathy in genome-wide analysis

J Feehally, M Farrall, A Boland, DP Gale… - Journal of the …, 2010 - journals.lww.com
Demographic and family studies support the existence of a genetic contribution to the
pathogenesis of IgA nephropathy, but results from genetic association studies of candidate …

[HTML][HTML] Pathogenesis of IgA nephropathy: current understanding and implications for development of disease-specific treatment

B Knoppova, C Reily, RG King, BA Julian… - Journal of clinical …, 2021 - mdpi.com
IgA nephropathy, initially described in 1968 as a kidney disease with glomerular
“intercapillary deposits of IgA-IgG”, has no disease-specific treatment and is a common …