Our understanding of the role of T cells in human disease is undergoing revision as a result
of the discovery of T‐helper 17 (Th17) cells, a unique CD4+ T‐cell subset characterized by …

T‐helper 17 (Th17) cells are characterized by producing interleukin‐17 (IL‐17, also called IL‐
17A), IL‐17F, IL‐21, and IL‐22 and potentially TNF‐α and IL‐6 upon certain stimulation. IL …

Dysregulated Th17 cell responses underlie multiple inflammatory and autoimmune
diseases, including autoimmune uveitis and its animal model, EAU. However, clinical trials …

T helper (Th) cell subsets secrete cytokines that regulate other immune cells. Interleukin (IL)-
17 and IL-22 belong to a new class of cytokines with predominant effects on epithelial cells …

Purpose Secukinumab, a fully human anti–interleukin-17A monoclonal antibody, exhibited
promising activity in a proof-of-concept study when administered in intravenous (IV) doses to …

The eye, as currently viewed, is neither immunologically ignorant nor sequestered from the
systemic environment. The eye utilises distinct immunoregulatory mechanisms to preserve …

Autoimmune uveitis is a complex group of sight-threatening diseases that arise without a
known infectious trigger. The disorder is often associated with immunological responses to …

Abstract IL-17-producing CD8+ T cells (Tc17) appear to play a role in a range of conditions,
such as autoimmunity and cancer. Thus far, Tc17 cells have been only marginally studied …

Although it has been known that γ δ T cells may play an important role in the immune
response to infection of Mycobacterium tuberculosis (M. tb), the mechanisms by which the γ …

April 25 and 26, 2008, in Fort Lauderdale, Florida. This conference series, funded by the
ARVO Foundation for Eye Research through a grant from Pfizer Ophthalmics, provides an …