Psoriasis is a chronic inflammatory disease characterised by sharply demarcated
erythematous and scaly skin lesions accompanied by systemic manifestations. Classified by …

Research on psoriasis pathogenesis has largely increased knowledge on skin biology in
general. In the past 15 years, breakthroughs in the understanding of the pathogenesis of …

Background Generalized pustular psoriasis (GPP) is a rare, life-threatening, inflammatory
skin disease characterized by widespread eruption of sterile pustules. Interleukin-36 …

Progress in understanding of the mechanisms underlying chronic inflammatory skin
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …

Generalized pustular psoriasis (GPP) is a rare, potentially life-threatening disease
characterized by episodes of widespread sterile macroscopic pustules, with or without …

Inhibition of the Interleukin-36 Pathway for the Treatment of Generalized Pustular Psoriasis |
New England Journal of Medicine Skip to main content The New England Journal of Medicine …

Introduction: Generalized pustular psoriasis (GPP) is a rare, severe relapsing/remitting,
multisystem disease that can be difficult to treat. Recent clinical, histological, and genetic …

Background Spesolimab is an anti-interleukin-36 receptor monoclonal antibody approved to
treat generalised pustular psoriasis (GPP) flares. We aimed to assess the efficacy and safety …

Generalized pustular psoriasis (GPP) is a rare, severe form of pustular psoriasis
characterized by widespread, recurrent episodes of neutrophil-rich pustule formation in the …

Generalized pustular psoriasis (GPP) is a rare auto‐inflammatory skin disease characterised
by acute episodes of sterile pustule formation. Diagnosis and treatment of the disease have …