Poloxamer 407, also known by the trademark Pluronic® F127, is a water-soluble, non-ionic
triblock copolymer that is made up of a hydrophobic residue of polyoxypropylene (POP) …

Neprilysin (NEP) is an integral membrane-bound metallopeptidase with a wide spectrum of
substrates and physiological functions. It plays an important role in proteolytic processes in …

Saliva is a clear, watery biofluid produced by the salivary glands to protect and lubricate the
oral cavity. While mostly composed of water (99%), the chemical composition of saliva is …

The oral cavity is a major portal of entry for pathogens that may lead to changes in the
normal microflora [1]. The homeostasis of the oral cavity is maintained by saliva, an …

There is increasing evidence that deficient clearance of β-amyloid (Aβ) contributes to its
accumulation in late-onset Alzheimer disease (AD). Several Aβ-degrading enzymes …

Previous studies proved the effectiveness of an intravenous PEGylated liposomal
formulation of opiorphin (1 mg/mL) in protecting the drug from enzymatic degradation, and …

AN INSTANT NEW YORK TIMES BESTSELLER “Everything you ever wanted to know about
the gut (and then some).”—SELF Discover the secrets of your digestive system—and how to …

This paper is the 29th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …

Hydrogels are three-dimensional networks of hydrophilic polymers able to absorb and retain
a considerable amount of water or biological fluid while maintaining their structure. Among …

Peptides are known to play many important physiological roles in signaling. A large number
of peptides have been detected in mouse brain extracts using mass spectrometry-based …