Traditionally, lymphocytic interferon γ (IFN-γ) was considered to be a simple'booster'of
proinflammatory responses by microglia (brain-resident macrophages) during bacterial or …

Astrocytes and microglia are central players in a myriad of processes in the healthy and
diseased brain, ranging from metabolism to immunity. The crosstalk between these two cell …

Scope The gut microbiota plays a prominent role in gut–brain interactions and gut dysbiosis
is involved in neuroinflammation. However, specific probiotics targeting neuroinflammation …

APOE and Trem2 are major genetic risk factors for Alzheimer's disease (AD), but how they
affect microglia response to Aβ remains unclear. Here we report an APOE isoform-specific …

Background Abnormal lipid accumulation has been recognized as a key element of immune
dysregulation in microglia whose dysfunction contributes to neurodegenerative diseases …

Obesity has been associated with oxidative stress. Obese patients are at increased risk for
diabetic cognitive dysfunction, indicating a pathological link between obesity, oxidative …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the
accumulation of amyloid-β (Aβ) plaques followed by intracellular neurofibrillary tangles …

Alzheimer's disease (AD) is the most common neurodegenerative disorder where the
accumulation of amyloid plaques and the formation of tau tangles are the prominent …

As one of most common and severe mental disorders, major depressive disorder (MDD)
significantly increases the risks of premature death and other medical conditions for patients …

High-fat diet (HFD) consumption is generally associated with an increased risk of cognitive
and emotional dysfunctions that constitute a sizeable worldwide health burden with …