Within-host evolution of bacterial pathogens
Whole-genome sequencing has opened the way for investigating the dynamics and
genomic evolution of bacterial pathogens during the colonization and infection of humans …
genomic evolution of bacterial pathogens during the colonization and infection of humans …
HIV infection
More than 75 million people worldwide have been infected with human immunodeficiency
virus (HIV), and there are now approximately 37 million individuals living with the infection …
virus (HIV), and there are now approximately 37 million individuals living with the infection …
Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor
Abstract Background SARS-CoV-2 causes COVID-19 which has a widely diverse disease
profile. The mechanisms underlying its pathogenicity remain unclear. We set out to identify …
profile. The mechanisms underlying its pathogenicity remain unclear. We set out to identify …
Extremely high mutation rate of HIV-1 in vivo
Rates of spontaneous mutation critically determine the genetic diversity and evolution of
RNA viruses. Although these rates have been characterized in vitro and in cell culture …
RNA viruses. Although these rates have been characterized in vitro and in cell culture …
Preexposure chemoprophylaxis for HIV prevention in men who have sex with men
RM Grant, JR Lama, PL Anderson… - … England Journal of …, 2010 - Mass Medical Soc
Background Antiretroviral chemoprophylaxis before exposure is a promising approach for
the prevention of human immunodeficiency virus (HIV) acquisition. Methods We randomly …
the prevention of human immunodeficiency virus (HIV) acquisition. Methods We randomly …
[HTML][HTML] Imperfect vaccination can enhance the transmission of highly virulent pathogens
AF Read, SJ Baigent, C Powers, LB Kgosana… - PLoS …, 2015 - journals.plos.org
Could some vaccines drive the evolution of more virulent pathogens? Conventional wisdom
is that natural selection will remove highly lethal pathogens if host death greatly reduces …
is that natural selection will remove highly lethal pathogens if host death greatly reduces …
A highly virulent variant of HIV-1 circulating in the Netherlands
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred
nine individuals with this variant had a 0.54 to 0.74 log10 increase (ie, a~ 3.5-fold to 5.5-fold …
nine individuals with this variant had a 0.54 to 0.74 log10 increase (ie, a~ 3.5-fold to 5.5-fold …
The phylogenomics of evolving virus virulence
JL Geoghegan, EC Holmes - Nature Reviews Genetics, 2018 - nature.com
How virulence evolves after a virus jumps to a new host species is central to disease
emergence. Our current understanding of virulence evolution is based on insights drawn …
emergence. Our current understanding of virulence evolution is based on insights drawn …
The adaptive evolution of virulence: a review of theoretical predictions and empirical tests
Why is it that some parasites cause high levels of host damage (ie virulence) whereas others
are relatively benign? There are now numerous reviews of virulence evolution in the …
are relatively benign? There are now numerous reviews of virulence evolution in the …
Microbial genome-wide association studies: lessons from human GWAS
The reduced costs of sequencing have led to whole-genome sequences for a large number
of microorganisms, enabling the application of microbial genome-wide association studies …
of microorganisms, enabling the application of microbial genome-wide association studies …