Protein kinase C (PKC) has been a tantalizing target for drug discovery ever since it was first
identified as the receptor for the tumour promoter phorbol ester in 1982. Although initial …

Vascular smooth muscle (VSM) plays an important role in the regulation of vascular function.
Identifying the mechanisms of VSM contraction has been a major research goal in order to …

Excessive mitochondrial fission is associated with the pathology of a number of
neurodegenerative diseases. Therefore, inhibitors of aberrant mitochondrial fission could …

Highlights•Protein–protein interactions are essential for almost all cell processes.•Peptides
are ideal candidates for targeting protein–protein interactions (PPIs).•We survey screening …

Vascular smooth muscle (VSM) plays an important role in maintaining vascular tone. In
addition to Ca 2+-dependent myosin light chain (MLC) phosphorylation, protein kinase C …

We previously demonstrated that beta II protein kinase C (βIIPKC) activity is elevated in
failing hearts and contributes to this pathology. Here we report that βIIPKC accumulates on …

After cardiac ischemia and reperfusion or reoxygenation (I/R), damaged mitochondria
propagate tissue injury by promoting cell death. One possible mechanism to protect from I/R …

Protein kinases are one of the most significant drug targets in the human proteome,
historically harnessed for the treatment of cancer, cardiovascular disease, and a growing …

Peptidomics techniques have identified hundreds of peptides that are derived from proteins
present mainly in the cytosol, mitochondria, and/or nucleus; these are termed intracellular …

The serine–threonine protein kinase, protein kinase C-δ (PKCδ), is emerging as a bi-
functional regulator of cell death and proliferation. Studies in PKCδ−/− mice have confirmed …