[HTML][HTML] Polymer-and lipid-based nanocarriers for ocular drug delivery: current status and future perspectives

H Han, S Li, M Xu, Y Zhong, W Fan, J Xu, T Zhou… - Advanced Drug Delivery …, 2023 - Elsevier
Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of
over 43 million blindness. However, efficient drug delivery to treat ocular diseases …

Bile acids and their derivatives as potential modifiers of drug release and pharmacokinetic profiles

N Pavlović, S Goločorbin-Kon, M Ðanić… - Frontiers in …, 2018 - frontiersin.org
Bile acids have received considerable interest in the drug delivery research due to their
peculiar physicochemical properties and biocompatibility. The main advantage of bile acids …

Penetration enhancers in ocular drug delivery

RV Moiseev, PWJ Morrison, F Steele… - Pharmaceutics, 2019 - mdpi.com
There are more than 100 recognized disorders of the eye. This makes the development of
advanced ocular formulations an important topic in pharmaceutical science. One of the ways …

Advanced formulation approaches for ocular drug delivery: state-of-the-art and recent patents

EB Souto, J Dias-Ferreira, A López-Machado… - Pharmaceutics, 2019 - mdpi.com
The eye presents extensive perspectives and challenges for drug delivery, mainly because
of the extraordinary capacity, intrinsic to this path, for drugs to permeate into the main …

Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas

L Li, J Hou, X Liu, Y Guo, Y Wu, L Zhang, Z Yang - Biomaterials, 2014 - Elsevier
BRAF gene mutation is found in more than 60% of malignant melanomas, which are difficult
to treat. In this study, a new tumor-targeting liposome was developed to deliver anti-BRAF …

Transfersomes: a revolutionary nanosystem for efficient transdermal drug delivery

MW Akram, H Jamshaid, FU Rehman, M Zaeem… - AAPS …, 2022 - Springer
Transdermal delivery system has gained significance in drug delivery owing to its
advantages over the conventional delivery systems. However, the barriers of stratum …

Investigating the potential of employing bilosomes as a novel vesicular carrier for transdermal delivery of tenoxicam

AM Al-Mahallawi, AA Abdelbary… - International journal of …, 2015 - Elsevier
Bilosomes represent an evolving vesicular carrier that have been explored for oral vaccines
delivery based on its ability to resist enzymes and bile salts in the gastrointestinal tract (GIT) …

Formulation and development of tacrolimus-gellan gum nanoformulation for treatment of dry eye disease

D Modi, J Nirmal, MH Warsi, M Bhatia, N Hasan… - Colloids and Surfaces B …, 2022 - Elsevier
The present study aimed at the development and evaluation of tacrolimus gellan gum
nanoparticles (TGNPs) for the effective management of dry eye disease (DED) following …

Liposomes in topical ophthalmic drug delivery: an update

R Agarwal, I Iezhitsa, P Agarwal, NA Abdul Nasir… - Drug …, 2016 - Taylor & Francis
Topical route of administration is the most commonly used method for the treatment of
ophthalmic diseases. However, presence of several layers of permeation barriers starting …

Development of acetazolamide loaded bilosomes for improved ocular delivery: Preparation, characterization and in vivo evaluation

AM Mohsen, A Salama, AA Kassem - Journal of Drug Delivery Science and …, 2020 - Elsevier
Acetazolamide (ACZ), a carbonic anhydrase inhibitor, is employed to decrease the
intraocular pressure (IOP) in glaucoma patients. ACZ is characterized by low aqueous …