Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

This review is the introduction to a special issue concerning, glutathione (GSH), the most
abundant low molecular weight thiol compound synthesized in cells. GSH plays critical roles …

Glutathione (GSH) is a ubiquitous intracellular peptide with diverse functions that include
detoxification, antioxidant defense, maintenance of thiol status, and modulation of cell …

Free radical-induced macromolecular damage has been studied extensively as a
mechanism of oxidative stress, but large-scale intervention trials with free radical …

Data about the toxicological interactions of MPs and heavy metals in biota is limited,
particularly in fish early life stages. This study aimed to evaluate the toxicological effects of …

Reactive oxygen species, either directly or via the formation of lipid peroxidation products,
may play a role in enhancing inflammation through the activation of stress kinases (c-Jun …

Glutathione (GSH) is a tripeptide composed of glutamate, cysteine, and glycine. The first and
rate-limiting step in GSH synthesis is catalyzed by glutamate cysteine ligase (GCL …

The evaluation of the interaction between microplastics (MPs) and heavy metals is of special
importance for risk assessment. In this study, zebrafish (Danio rerio) were exposed to MPs (2 …

Redox biology has evolved from studies of the pathology that involves oxidants to an
understanding of how oxidants participate in normal as well as aberrant signal transduction …

Glutathione (γ-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular
antioxidant thiol and is central to redox defense during oxidative stress. GSH metabolism is …