The gut microbiome and inflammatory bowel diseases

Y Shan, M Lee, EB Chang - Annual review of medicine, 2022 - annualreviews.org
Inflammatory bowel diseases (IBD) arise from a convergence of genetic risk, environmental
factors, and gut microbiota, where each is necessary but not sufficient to cause disease …

Diversity and dynamism of IgA− microbiota interactions

KE Huus, C Petersen, BB Finlay - Nature Reviews Immunology, 2021 - nature.com
IgA mediates microbial homeostasis at the intestinal mucosa. Within the gut, IgA acts in a
context-dependent manner to both prevent and promote bacterial colonization and to …

Reductions in anti-inflammatory gut bacteria are associated with depression in a sample of young adults

RT Liu, AD Rowan-Nash, AE Sheehan… - Brain, behavior, and …, 2020 - Elsevier
We assessed the gut microbiota of 90 American young adults, comparing 43 participants
with major depressive disorder (MDD) and 47 healthy controls, and found that the MDD …

[HTML][HTML] Interaction between commensal bacteria, immune response and the intestinal barrier in inflammatory bowel disease

Y Chen, W Cui, X Li, H Yang - Frontiers in Immunology, 2021 - frontiersin.org
In inflammatory bowel disease (IBD), intestinal mucosa cell and intestinal epithelial cell are
severely damaged, and then their susceptibility to bacteria increases, so many commensal …

The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn's disease

TK Pedersen, EM Brown, DR Plichta, J Johansen… - Immunity, 2022 - cell.com
Reciprocal interactions between host T helper cells and gut microbiota enforce local
immunological tolerance and modulate extra-intestinal immunity. However, our …

Biological chemotaxis-guided self-thermophoretic nanoplatform augments colorectal cancer therapy through autonomous mucus penetration

ZH Wang, M Chu, N Yin, W Huang, W Liu, Z Zhang… - Science …, 2022 - science.org
Oral drug delivery systems have great potential to treat colorectal cancer (CRC). However,
the drug delivery efficiency is restricted by limited CRC-related intestine positioning and …

Not all fibers are born equal; variable response to dietary fiber subtypes in IBD

H Armstrong, I Mander, Z Zhang, D Armstrong… - Frontiers in …, 2021 - frontiersin.org
Diet provides a safe and attractive alternative to available treatment options in a variety of
diseases; however, research has only just begun to elucidate the role of diet in chronic …

Label or concept–what is a pathobiont?

L Jochum, B Stecher - Trends in microbiology, 2020 - cell.com
An increasing number of microorganisms are classified as' pathobionts'(ie, organisms that
can cause harm under certain circumstances) but there exist no universally used criteria for …

Lychee (Litchi chinensis Sonn.) Pulp Phenolics Activate the Short-Chain Fatty Acid-Free Fatty Acid Receptor Anti-inflammatory Pathway by Regulating Microbiota and …

G Huang, Z Wang, G Wu, R Zhang… - Journal of Agricultural …, 2021 - ACS Publications
The preventive effect of lychee pulp phenolics (LPP) on dextran sulfate sodium (DSS)-
induced colitis of mice and its underlying mechanisms were investigated in this research …

[HTML][HTML] Pathobionts in inflammatory bowel disease: origins, underlying mechanisms, and implications for clinical care

A Gilliland, JJ Chan, TJ De Wolfe, H Yang, BA Vallance - Gastroenterology, 2023 - Elsevier
The gut microbiota plays a significant role in the pathogenesis of both forms of inflammatory
bowel disease (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC). While …