Auranofin synergizes with the PARP inhibitor olaparib to induce ROS-mediated cell death in mutant p53 cancers
Auranofin (AF) is a potent, off-patent thioredoxin reductase (TrxR) inhibitor that efficiently
targets cancer via reactive oxygen species (ROS)-and DNA damage-mediated cell death …
targets cancer via reactive oxygen species (ROS)-and DNA damage-mediated cell death …
Auranofin repurposing for lung and pancreatic cancer: low CA12 expression as a marker of sensitivity in patient-derived organoids, with potentiated efficacy by AKT …
C Deben, LF Boullosa, FR Fortes… - Journal of Experimental …, 2024 - Springer
Background This study explores the repurposing of Auranofin (AF), an anti-rheumatic drug,
for treating non-small cell lung cancer (NSCLC) adenocarcinoma and pancreatic ductal …
for treating non-small cell lung cancer (NSCLC) adenocarcinoma and pancreatic ductal …
Auranofin enhances the antibacterial effects of ertapenem against carbapenem-resistant Escherichia coli
DH Lee, YB Eom - Diagnostic Microbiology and Infectious Disease, 2024 - Elsevier
The prevalence of carbapenem-resistant Escherichia coli (CREC) is increasing worldwide,
and infections caused by CREC are associated with substantial morbidity and mortality …
and infections caused by CREC are associated with substantial morbidity and mortality …
Structure, stability, and dynamics of inclusion complexes formed from auranofin derivatives and hydroxypropyl-β-cyclodextrin
HF Dos Santos, CPA Anconi - Journal of Inclusion Phenomena and …, 2024 - Springer
The inclusion compounds of auranofin (AF) and its iodide derivative (AF-I) with HP-β-CD
were recently identified and characterized experimentally. In the present work, classical …
were recently identified and characterized experimentally. In the present work, classical …
How preclinical models can help to dissect the sex related mechanisms sustaining liver disease: the role of estrogen mediated antioxidant response in NAFLD
A Smiriglia - 2024 - flore.unifi.it
My PhD project aimed to investigate the role of estrogen in reversing the mechanisms of
MASLD, such as lipid accumulation and oxidative stress, through activation of the …
MASLD, such as lipid accumulation and oxidative stress, through activation of the …