Therapies with genetically modified T cells that express chimeric antigen receptors (CARs)
specific for CD19 or B cell maturation antigen (BCMA) are approved to treat certain B cell …

The steadfast advance of the synthetic biology field has enabled scientists to use genetically
engineered cells, instead of small molecules or biologics, as the basis for the development …

Malignant transformation and tumour progression are associated with cancer-cell softening.
Yet how the biomechanics of cancer cells affects T-cell-mediated cytotoxicity and thus the …

Immunotherapy has become a powerful clinical strategy for treating cancer. The number of
immunotherapy drug approvals has been increasing, with numerous treatments in clinical …

The immune checkpoint blockade (ICB) therapy has revolutionized the field of cancer
treatment, while low response rates and systemic toxicity limit its clinical outcomes. With the …

Chimeric antigen receptor (CAR) T cell-based immunotherapy, approved by the US Food
and Drug Administration, has shown curative potential in patients with haematological …

Chimeric antigen receptor (CAR) T cell therapy relies on the ex vivo manipulation of patient
T cells to create potent, cancer-targeting therapies, shown to be capable of inducing …

Focused ultrasound can deliver energy safely and non-invasively into tissues at depths of
centimetres. Here we show that the genetics and cellular functions of chimeric antigen …

Ultrasonic neuromodulation is a rapidly growing field, in which low-intensity ultrasound (US)
is delivered to nervous system tissue, resulting in transient modulation of neural activity. This …

The blood brain barrier (BBB) plays a critically important role in the regulation of central
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …