Lipoprotein (a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement

F Kronenberg, S Mora, ESG Stroes… - European heart …, 2022 - academic.oup.com
Abstract This 2022 European Atherosclerosis Society lipoprotein (a)[Lp (a)] consensus
statement updates evidence for the role of Lp (a) in atherosclerotic cardiovascular disease …

Polygenic risk scores for cardiovascular disease: a scientific statement from the American Heart Association

JW O'Sullivan, S Raghavan, C Marquez-Luna… - Circulation, 2022 - Am Heart Assoc
Cardiovascular disease is the leading contributor to years lost due to disability or premature
death among adults. Current efforts focus on risk prediction and risk factor mitigation ‚which …

Lipoprotein (a) and its significance in cardiovascular disease: a review

FD Lau, RP Giugliano - JAMA cardiology, 2022 - jamanetwork.com
Importance Lipoprotein (a)(Lp [a]) is a low-density lipoprotein (LDL) cholesterol–like particle
bound to apolipoprotein (a). This novel marker of cardiovascular disease acts through …

Lipid and lipoprotein metabolism

KR Feingold - Endocrinology and Metabolism Clinics, 2022 - endo.theclinics.com
Lipids are insoluble in water and therefore cholesterol and triglycerides need to be
transported in association with proteins (ie, lipoproteins) in the bloodstream. Lipoproteins …

[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene

S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …

A focused update to the 2019 NLA scientific statement on use of lipoprotein (a) in clinical practice

ML Koschinsky, A Bajaj, MB Boffa, DL Dixon… - Journal of clinical …, 2024 - Elsevier
Since the 2019 National Lipid Association (NLA) Scientific Statement on Use of Lipoprotein
(a) in Clinical Practice was issued, accumulating epidemiological data have clarified the …

Protein-coding repeat polymorphisms strongly shape diverse human phenotypes

RE Mukamel, RE Handsaker, MA Sherman, AR Barton… - Science, 2021 - science.org
Many human proteins contain domains that vary in size or copy number because of variable
numbers of tandem repeats (VNTRs) in protein-coding exons. However, the relationships of …

Aspirin for primary prevention of cardiovascular events in relation to lipoprotein (a) genotypes

P Lacaze, A Bakshi, M Riaz, G Polekhina… - Journal of the American …, 2022 - jacc.org
Background The role of aspirin in reducing lipoprotein (a)-mediated atherothrombotic events
in primary prevention is not established. Objectives This study sought to assess whether low …

[HTML][HTML] Lipoprotein (a) measurement issues: are we making a mountain out of a molehill?

F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract Lipoprotein (a)[Lp (a)] became besides LDL cholesterol one of the most attractive
targets for intervention in cardiovascular disease. Strong genetic evidence supports the …

[HTML][HTML] Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults

L Shi, Y Yuan, Y Xiao, P Long, W Li, Y Yu, Y Liu… - Environment …, 2021 - Elsevier
Background Exposure to metals/metalloids from both the natural environment and
anthropogenic sources have a complex influence on human health. However, relatively few …