Molecular mechanisms of atopic dermatitis pathogenesis

J Sroka-Tomaszewska, M Trzeciak - International journal of molecular …, 2021 - mdpi.com
Atopic dermatitis is a chronic, non-infectious inflammatory dermatosis. Acharacteristic
feature is persistent itching of the skin. The chronic, relapsing course of the disease …

Early life microbial exposures and allergy risks: opportunities for prevention

H Renz, C Skevaki - Nature Reviews Immunology, 2021 - nature.com
Allergies, including asthma, food allergy and atopic dermatitis, are increasing in prevalence,
particularly in westernized countries. Although a detailed mechanistic explanation for this …

Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease

C Hoskinson, DLY Dai, KL Del Bel, AB Becker… - Nature …, 2023 - nature.com
Allergic diseases affect millions of people worldwide. An increase in their prevalence has
been associated with alterations in the gut microbiome, ie, the microorganisms and their …

Allergen immunotherapy in children user's guide

M Alvaro‐Lozano, CA Akdis, M Akdis… - Pediatric allergy and …, 2020 - Wiley Online Library
Allergen immunotherapy is a cornerstone in the treatment of allergic children. The clinical
efficiency relies on a well‐defined immunologic mechanism promoting regulatory T cells and …

Research progress in atopic march

L Yang, J Fu, Y Zhou - Frontiers in immunology, 2020 - frontiersin.org
The incidence of allergic diseases continues to rise. Cross-sectional and longitudinal
studies have indicated that allergic diseases occur in a time-based order: from atopic …

The promise of the gut microbiome as part of individualized treatment strategies

DA Schupack, RAT Mars, DH Voelker… - Nature reviews …, 2022 - nature.com
Variability in disease presentation, progression and treatment response has been a central
challenge in medicine. Although variability in host factors and genetics are important, it has …

Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial

JR Chalmers, RH Haines, LE Bradshaw… - The Lancet, 2020 - thelancet.com
Background Skin barrier dysfunction precedes eczema development. We tested whether
daily use of emollient in the first year could prevent eczema in high-risk children. Methods …

Epicutaneous sensitization in the development of food allergy: what is the evidence and how can this be prevented?

HA Brough, KC Nadeau, SB Sindher, SS Alkotob… - Allergy, 2020 - Wiley Online Library
There is increasing evidence regarding the importance of allergic sensitization through the
skin. In this review, we provide an overview of the atopic march and immune mechanism …

[HTML][HTML] The burden of asthma, hay fever and eczema in adults in 17 countries: GAN Phase I study

K Mortimer, M Lesosky, L García-Marcos… - European …, 2022 - Eur Respiratory Soc
Aims Asthma, hay fever and eczema are three common chronic conditions. There have been
no recent multi-country data on the burden of these three conditions in adults; the aims of …

Epithelial barrier repair and prevention of allergy

E Goleva, E Berdyshev… - The Journal of clinical …, 2019 - Am Soc Clin Investig
Allergic diseases have in common a dysfunctional epithelial barrier, which allows the
penetration of allergens and microbes, leading to the release of type 2 cytokines that drive …