Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Hyaluronan (HA) is a linear polysaccharide with disaccharide repeats of d-glucuronic acid
and N-acetyl-d-glucosamine. It is evolutionarily conserved and abundantly expressed in the …

With the introduction of multiple new agents, the role of immunotherapy is rapidly expanding
across all malignancies. Bladder cancer is known to be immunogenic and is responsive to …

The extracellular matrix (ECM) spatiotemporally controls cell fate; however, dysregulation of
ECM remodeling can lead to tumorigenesis and cancer development by providing favorable …

Simple Summary Proteolytic enzymes, such as matrix metalloproteinases, plasminogen
activators and cathepsins, as well as non-proteolytic enzymatic partners, such as …

Objectives With the advent of novel genomic and transcriptomic technologies, new urinary
biomarkers have been identified and tested for bladder cancer (BCa) surveillance. To …

Hyaluronidases are a family of five human enzymes that have been differentially implicated
in the progression of many solid tumor types, both clinically and in functional studies …

Many pathological changes in solid tumours are caused by the accumulation of genetic
mutations and epigenetic molecular alterations. In addition, tumour progression is …

BACKGROUND: Cancer biomarkers are the backbone for the implementation of
individualized approaches to bladder cancer (BCa). Hyaluronic acid (HA) and all 7 members …

Background Although pancreatic ductal adenocarcinoma is characterized by an abundant
stroma enriched with hyaluronan (HA), the prognostic impact of HA and its regulators …