The blood–brain barrier (BBB) is a dynamic interface responsible for maintaining the central
nervous system homeostasis. Its unique characteristics allow protecting the brain from …

The vascular basement membrane contributes to the integrity of the blood-brain barrier
(BBB), which is formed by brain capillary endothelial cells (BCECs). The BCECs receive …

Numerous studies have documented increases in matrix metalloproteinases (MMPs),
specifically MMP-9 levels following stroke, with such perturbations associated with …

Recanalization therapy is increasingly used in the treatment of acute ischemic stroke.
However, in about one third of these patients, recanalization is followed by …

The blood-brain barrier (BBB) is formed by the endothelial cells of cerebral microvessels,
providing a dynamic interface between the peripheral circulation and the central nervous …

Matrix metalloproteinases (MMPs) disrupt the blood—brain barrier (BBB) during reperfusion.
Occludin and claudins are recently described tight junction proteins (TJPs) that form the …

Oxidative stress occurs in a variety of disease settings and is strongly linked to the
development of neuron death and neuronal dysfunction. Cells are equipped with numerous …

The blood–brain barrier (BBB) is formed primarily to protect the brain microenvironment from
the influx of plasma components, which may disturb neuronal functions. The BBB is a …

The brain is in many ways an immunologically and pharmacologically privileged site. The
blood–brain barrier (BBB) of the cerebrovascular endothelium and its participation in the …

Regulation of the extracellular matrix by proteases and protease inhibitors is a fundamental
biological process for normal growth, development and repair in the CNS. Matrix …