Recent advances on small molecules in osteogenic differentiation of stem cells and the underlying signaling pathways
Bone-related diseases are major contributors to morbidity and mortality in elderly people
and the current treatments result in insufficient healing and several complications. One of the …
and the current treatments result in insufficient healing and several complications. One of the …
Three-dimensional monolithic porous structures assembled from fragmented electrospun nanofiber mats/membranes: Methods, properties, and applications
Abstract Three-dimensional (3D) monolithic structures (ie, aerogels/sponges/scaffolds)
assembled from fragmented electrospun nanofiber mats/membranes represent an emerging …
assembled from fragmented electrospun nanofiber mats/membranes represent an emerging …
Materials-based nanotherapeutics for injured and diseased bone
Severe injuries and diseases of bone tissue caused by congenital disorder, extrinsic trauma,
infection, and osteosarcoma resection face significant challenges for complete recovery. The …
infection, and osteosarcoma resection face significant challenges for complete recovery. The …
Engineering the MSC secretome: a hydrogel focused approach
The therapeutic benefits of exogenously delivered mesenchymal stromal/stem cells (MSCs)
have been largely attributed to their secretory properties. However, clinical translation of …
have been largely attributed to their secretory properties. However, clinical translation of …
Functionalization of PCL-3D electrospun nanofibrous scaffolds for improved BMP2-induced bone formation
Abstract Bone morphogenic protein 2 (BMP2) is a key growth factor for bone regeneration,
possessing FDA approval for orthopedic applications. BMP2 is often required in …
possessing FDA approval for orthopedic applications. BMP2 is often required in …
Dual drug delivery system of teicoplanin and phenamil based on pH-sensitive silk fibroin/sodium alginate hydrogel scaffold for treating chronic bone infection
H Motasadizadeh, M Tavakoli, S Damoogh… - Biomaterials …, 2022 - Elsevier
For effective treatment of infected bone, it is essential to use local drug delivery systems with
the ability to deliver both antibiotics and osteoinductive factors. Herein, a pH-sensitive silk …
the ability to deliver both antibiotics and osteoinductive factors. Herein, a pH-sensitive silk …
[HTML][HTML] Stem cells, growth factors and scaffolds in craniofacial regenerative medicine
V Tollemar, ZJ Collier, MK Mohammed, MJ Lee… - Genes & diseases, 2016 - Elsevier
Current reconstructive approaches to large craniofacial skeletal defects are often
complicated and challenging. Critical-sized defects are unable to heal via natural …
complicated and challenging. Critical-sized defects are unable to heal via natural …
Wnt-modified materials mediate asymmetric stem cell division to direct human osteogenic tissue formation for bone repair
The maintenance of human skeletal stem cells (hSSCs) and their progeny in bone defects is
a major challenge. Here, we report on a transplantable bandage containing a three …
a major challenge. Here, we report on a transplantable bandage containing a three …
Long-term induction of endogenous BMPs growth factor from antibacterial dual network hydrogels for fast large bone defect repair
Q Yao, Y Liu, Y Pan, Y Li, L Xu, Y Zhong… - Journal of Colloid and …, 2022 - Elsevier
Osteoinductive, osteoconductive, and antibacterial properties of bone repair materials play
important roles in regulating the successful bone regeneration. In the present work, we …
important roles in regulating the successful bone regeneration. In the present work, we …
Intracellular co-delivery of Sr ion and phenamil drug through mesoporous bioglass nanocarriers synergizes BMP signaling and tissue mineralization
Inducing differentiation and maturation of resident multipotent stem cells (MSCs) is an
important strategy to regenerate hard tissues in mal-calcification conditions. Here we …
important strategy to regenerate hard tissues in mal-calcification conditions. Here we …