Protozoan parasites have developed elaborate motility systems that facilitate infection and
dissemination. For example, amoebae use actin-rich membrane extensions called …

Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of
immunologically privileged erythrocytes provides a relatively protective niche as well as …

Apicomplexan parasites are leading causes of human and livestock diseases such as
malaria and toxoplasmosis, yet most of their genes remain uncharacterized. Here, we …

Toxoplasmosis is the clinical and pathological consequence of acute infection with the
obligate intracellular apicomplexan parasite Toxoplasma gondii. Symptoms result from …

Toxoplasma gondii is a parasite of humans and animals, and a model for other
apicomplexans including Plasmodium spp., the causative agents of malaria. Despite many …

The malaria parasite replicates within an intraerythrocytic parasitophorous vacuole (PV).
Eventually, in a tightly regulated process called egress, proteins of the PV and intracellular …

This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years,
including new information on the genomics, epigenomics and proteomics of T. gondii as well …

Cyclic GMP (cGMP)-dependent protein kinase (protein kinase G [PKG]) is essential for
microneme secretion, motility, invasion, and egress in apicomplexan parasites, However …

Many critical events in the Plasmodium life cycle rely on the controlled release of Ca2+ from
intracellular stores to activate stage-specific Ca2+-dependent protein kinases. Using the …

The obligate intracellular lifestyle of apicomplexan parasites necessitates an invasive phase
underpinned by timely and spatially controlled secretion of apical organelles termed …