Recent advances in genome sequencing technologies provide unprecedented opportunities
to characterize individual genomic landscapes and identify mutations relevant for diagnosis …

Next-generation sequencing (NGS) technologies have been used in diverse ways to
investigate various aspects of chromatin biology by identifying genomic loci that are bound …

Motivation: RNA-seq has been extensively used for transcriptome study. Quality control (QC)
is critical to ensure that RNA-seq data are of high quality and suitable for subsequent …

The human genome encodes hundreds of transfer RNA (tRNA) genes but their individual
contribution to the tRNA pool is not fully understood. Deep sequencing of tRNA transcripts …

With the advent of ChIP-seq multiplexing technologies and the subsequent increase in ChIP-
seq throughput, the development of working standards for the quality assessment of ChIP …

Determining the effect of DNA methylation on chromatin structure and function in higher
organisms is challenging due to the extreme complexity of epigenetic regulation. We studied …

In multiple sclerosis (MS), soluble tumor necrosis factor (TNF) is detrimental via activation of
TNF receptor 1 (TNFR1), whereas transmembrane TNF is beneficial primarily by activating …

Sequencing has revolutionized biology by permitting the analysis of genomic variation at an
unprecedented resolution. High-throughput sequencing is fast and inexpensive, making it …

The linear sequence of DNA provides invaluable information about genes and their
regulatory elements along chromosomes. However, to fully understand gene function and …

Sequencing small quantities of DNA is important for applications ranging from the assembly
of uncultivable microbial genomes to the identification of cancer-associated mutations. To …