Cell signalling and endocytic membrane trafficking have traditionally been viewed as distinct
processes. Although our present understanding is incomplete and there are still great …

▪ Abstract Eukaryotic cells use actin polymerization to change shape, move, and internalize
extracellular materials by phagocytosis and endocytosis, and to form contractile structures …

Dynamin is essential for clathrin-dependent coated vesicle formation. It is required for
membrane budding at a late stage during the transition from a fully formed pit to a pinched …

Endophilin‐A1 is a BAR domain‐containing protein enriched at synapses and is implicated
in synaptic vesicle endocytosis. It binds to dynamin and synaptojanin via a C‐terminal SH3 …

▪ Abstract Clathrin was discovered nearly 25 years ago. Since then, a large number of other
proteins that participate in the process by which clathrin-coated vesicles retrieve synaptic …

▪ Abstract Dynamin, a 100-kDa GTPase, is an essential component of vesicle formation in
receptor-mediated endocytosis, synaptic vesicle recycling, caveolae internalization, and …

▪ Abstract There has recently been considerable progress in understanding the regulation of
clathrin-coated vesicle (CCV) formation and function. These advances are due to the …

A safe and controlled manipulation of endocytosis in vivo may have disruptive therapeutic
potential. Here, we demonstrate that the anti-emetic/anti-psychotic prochlorperazine can be …

A number of recent studies have provided new insights into the complexity of the endocytic
pathways originating at the plasma membrane of mammalian cells. Many of the molecules …

▪ Abstract Internalization of receptors, lipids, pathogens, and other cargo at the plasma
membrane involves several different pathways and requires coordinated interactions …