Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

Hippo pathway components are structurally and functionally conserved and are notable for
their role in controlling organ size. More diverse functions of the Hippo pathway have been …

INTRODUCTION The remarkable development of a single cell, the zygote, into the full
organism occurs through a complex series of division and differentiation events that …

During pre-implantation development, the mammalian embryo self-organizes into the
blastocyst, which consists of an epithelial layer encapsulating the inner-cell mass (ICM) …

The skin is a squamous epithelium that is continuously renewed by a population of basal
layer stem/progenitor cells and can heal wounds. Here, we show that the transcription …

During mouse preimplantation embryo development, totipotent blastomeres generate the
first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In …

Gene regulatory networks and tissue morphogenetic events drive the emergence of shape
and function: the pillars of embryo development. Although model systems offer a window …

During mouse pre-implantation development, the formation of the blastocoel, a fluid-filled
lumen, breaks the radial symmetry of the blastocyst. The factors that control the formation …

Early embryogenesis is a conserved and self-organized process. In the mammalian embryo,
the potential for self-organization is manifested in its extraordinary developmental plasticity …

To implant in the uterus, the mammalian embryo first specifies two cell lineages: the
pluripotent inner cell mass that forms the fetus, and the outer trophectoderm layer that forms …