Oral administration is the most commonly used route for drug delivery owing to its cost-
effectiveness, ease of administration, and high patient compliance. However, the absorption …

The application of mesoporous silica nanoparticles (MSNs) as drug delivery systems to
deliver drugs, proteins, and genes has expanded considerably in recent years, using in vitro …

Developing a mechanistic understanding of the impact of food structure and composition on
human health has increasingly involved simulating digestion in the upper gastrointestinal …

Lipid-based formulations (LBFs) have demonstrated a great potential in enhancing the oral
absorption of poorly water-soluble drugs. However, construction of in vitro and in vivo …

Drug-receptor interaction plays an important role in a series of biological effects, such as cell
proliferation, immune response, tumor metastasis, and drug delivery. Therefore, the …

Porous silica-based drug delivery systems have shown considerable promise for improving
the oral delivery of poorly water-soluble drugs. More specifically, micro-and meso-porous …

Within preclinical research, the pig has become an important model in regulatory toxicology
and pharmacokinetics, to assess oral dosage forms and to compare different formulation …

Objectives In pharmaceutical drug development, preclinical tests in animal models are
essential to demonstrate whether the new drug is orally bioavailable and to gain a first …

Mesoporous silica nanoparticles (MSNs) have been widely used in biomedical applications.
However, most studies have been limited to spherical MSNs, while non-spherical MSNs …

Suberoylanilide hydroxamic acid (SAHA) or vorinostat (VOR) is a potent inhibitor of class I
histone deacetylases (HDACs) that is approved for the treatment of cutaneous T-cell …