Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Isoforms of the casein kinase 1 (CK1) family have been shown to phosphorylate key
regulatory molecules involved in cell cycle, transcription and translation, the structure of the …

Abstract Purpose of Review Review current understanding of both canonical and non-
canonical Wnt signaling in cancer and provide updated knowledge in current clinical trials of …

Casein kinase 1α (CK1α) is a multifunctional protein belonging to the CK1 protein family that
is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to …

Epithelial ovarian cancer (EOC) has one of the highest death to incidence ratios among all
cancers. High grade serous ovarian carcinoma (HGSOC) is the most common and deadliest …

Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases
are tightly regulated in the cell and play crucial regulatory roles in multiple cellular …

The term 'casein kinase'has been widely used for decades to denote protein kinases sharing
the ability to readily phosphorylate casein in vitro. These fall into three main classes: two of …

Acquisition of chemoresistance and metastatic phenotype are the major causes of breast
cancer treatment failure and cancer-related mortality. Recently, a plethora of experimental …

In a continuous search for the improvement of antitumor therapies, the inhibition of the Wnt
signaling pathway has been recognized as a promising target. The altered functioning of the …