Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
NJ Hogrebe, M Ishahak, JR Millman - Cell Stem Cell, 2023 - cell.com
The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview
Since human embryonic stem cells were first differentiated to beating cardiomyocytes a
decade ago, interest in their potential applications has increased exponentially. This has …
decade ago, interest in their potential applications has increased exponentially. This has …
Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics
Human pluripotent stem cells (hPSCs) provide powerful resources for application in
regenerative medicine and pharmaceutical development. In the past decade, various …
regenerative medicine and pharmaceutical development. In the past decade, various …
Physical cues of biomaterials guide stem cell differentiation fate
Millions of people lose or damage their organs or tissues due to disease, birth defects, or
accidents each year. Stem cells, such as embryonic stem cells (ESCs), induced pluripotent …
accidents each year. Stem cells, such as embryonic stem cells (ESCs), induced pluripotent …
A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues
Engineered myocardial tissues can be used to elucidate fundamental features of myocardial
biology, develop organotypic in vitro model systems, and as engineered tissue constructs for …
biology, develop organotypic in vitro model systems, and as engineered tissue constructs for …
A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation
Y Lei, DV Schaffer - … of the National Academy of Sciences, 2013 - National Acad Sciences
Human pluripotent stem cells (hPSCs), including human embryonic stem cells and induced
pluripotent stem cells, are promising for numerous biomedical applications, such as cell …
pluripotent stem cells, are promising for numerous biomedical applications, such as cell …
A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability
PW Burridge, S Thompson, MA Millrod, S Weinberg… - PloS one, 2011 - journals.plos.org
Background The production of cardiomyocytes from human induced pluripotent stem cells
(hiPSC) holds great promise for patient-specific cardiotoxicity drug testing, disease …
(hiPSC) holds great promise for patient-specific cardiotoxicity drug testing, disease …
Process engineering of human pluripotent stem cells for clinical application
Human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem
cells, constitute an extremely attractive tool for cell therapy. However, flexible platforms for …
cells, constitute an extremely attractive tool for cell therapy. However, flexible platforms for …
Microwell-mediated control of embryoid body size regulates embryonic stem cell fate via differential expression of WNT5a and WNT11
Recently, various approaches for controlling the embryonic stem (ES) cell microenvironment
have been developed for regulating cellular fate decisions. It has been reported that the …
have been developed for regulating cellular fate decisions. It has been reported that the …
Scalable expansion of human pluripotent stem cells in suspension culture
Routine commercial and clinical applications of human pluripotent stem cells (hPSCs) and
their progenies will require increasing cell quantities that cannot be provided by …
their progenies will require increasing cell quantities that cannot be provided by …