Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that
controls several important aspects of mammalian cell function. mTOR activity is modulated …

Opioids produce strong analgesia but their use is limited by a paradoxical hypersensitivity
named opioid-induced hyperalgesia (OIH) that may be associated to analgesic tolerance. In …

Neuropathic pain is still an extremely important problem in today's medicine because
opioids, which are commonly used to reduce pain, have limited efficacy in this type of …

This study investigated the relationship between the pain of sciatic endometriosis and the
phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin …

The current paradigm of type 2 diabetes (T2D) is gluco-centric, being exclusively
categorized by glycemic characteristics. The gluco-centric paradigm views hyperglycemia as …

Schwannomatosis (SWNTS) is a genetic cancer predisposition syndrome that manifests as
multiple and often painful neuronal tumors called schwannomas (SWNs). While germline …

The hypothesis that pain can predispose to frailty development has been recently
investigated in several clinical studies suggesting that frailty and pain may share some …

Objective To explore the effects of inhibition of PI3K/Akt/mTOR signal pathway on chronic
neuropathic pain (CNP) and spinal microglia in a rat model of chronic constriction injury …

Injury of peripheral nerves can trigger neuropathic pain, producing allodynia and
hyperalgesia via peripheral and central sensitization. Recent studies have focused on the …

Objective This study was designed to explore the efficacy and feasibility of cognitive
behavioral therapy (CBT) along with pregabalin and compare it with pregabalin …