Forgotten and forbidden chemical reactions revitalised through continuous flow technology
A Bonner, A Loftus, AC Padgham… - Organic & Biomolecular …, 2021 - pubs.rsc.org
Continuous flow technology has played an undeniable role in enabling modern chemical
synthesis, whereby a myriad of reactions can now be performed with greater efficiency …
synthesis, whereby a myriad of reactions can now be performed with greater efficiency …
Continuous flow chemistry: where are we now? Recent applications, challenges and limitations
FM Akwi, P Watts - Chemical communications, 2018 - pubs.rsc.org
A general outlook of the changing face of chemical synthesis is provided in this article
through recent applications of continuous flow processing in both industry and academia …
through recent applications of continuous flow processing in both industry and academia …
[HTML][HTML] Continuous flow synthesis enabling reaction discovery
AI Alfano, J García-Lacuna, OM Griffiths, SV Ley… - Chemical …, 2024 - pubs.rsc.org
This article defines the role that continuous flow chemistry can have in new reaction
discovery, thereby creating molecular assembly opportunities beyond our current …
discovery, thereby creating molecular assembly opportunities beyond our current …
Flow technology for the genesis and use of (highly) reactive organometallic reagents
In the field of organic synthesis, the advent of flow chemistry and flow microreactor
technology represented a tremendous novelty in the way of thinking and performing …
technology represented a tremendous novelty in the way of thinking and performing …
Exploring ultrafast flow chemistry by autonomous self-optimizing platform
The rapid development of novel synthetic routes for pharmaceutical compounds is highly
attractive for overcoming pandemic and epidemic-prone diseases like COVID-19. Herein …
attractive for overcoming pandemic and epidemic-prone diseases like COVID-19. Herein …
Batch versus flow lithiation–substitution of 1, 3, 4‐oxadiazoles: Exploitation of unstable intermediates using flow chemistry
Oxadiazoles are a common motif in pharmaceutical chemistry, but few convenient methods
for their modification exist. A fast, convenient, high yielding and general α‐substitution of 1 …
for their modification exist. A fast, convenient, high yielding and general α‐substitution of 1 …
From p‐Xylene to Ibuprofen in Flow: Three‐Step Synthesis by a Unified Sequence of Chemoselective C−H Metalations
Ibuprofen was prepared from an inactive and inexpensive p‐xylene by three‐step flow
functionalizations through chemoselective metalations of benzyl positions in sequence …
functionalizations through chemoselective metalations of benzyl positions in sequence …
Development and Characterization of a Portable Flow Microreactor for Enhanced Bioconjugation Applications
Y Endo, Y Nakahara, R Shiroma… - … Process Research & …, 2024 - ACS Publications
The reliance of pharmaceutical production on batch reactors dating back to the 20th century
has exposed vulnerabilities in the supply chains of essential medicines, which were …
has exposed vulnerabilities in the supply chains of essential medicines, which were …
Enhanced Controllability of Fries Rearrangements Using High‐Resolution 3D‐Printed Metal Microreactor with Circular Channel
High‐resolution 3D‐printed stainless steel metal microreactors (3D‐PMRs) with different
cross‐sectional geometry are fabricated to control ultrafast intramolecular rearrangement …
cross‐sectional geometry are fabricated to control ultrafast intramolecular rearrangement …
Continuous-flow reactions mediated by main group organometallics
JH Harenberg, N Weidmann, P Knochel - Synlett, 2020 - thieme-connect.com
The generation of reactive organometallic reagents in batch is often complicated by the low
thermal stability of these important synthetic intermediates and can require low reaction …
thermal stability of these important synthetic intermediates and can require low reaction …