Significance: Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique to
distinguish the unique molecular environment of fluorophores. FLIM measures the time a …

Fluorescence lifetime imaging (FLIm) is an optical spectroscopic imaging technique capable
of real‐time assessments of tissue properties in clinical settings. Label‐free FLIm is sensitive …

Real-time imaging of countless femtosecond dynamics requires extreme speeds orders of
magnitude beyond the limits of electronic sensors. Existing femtosecond imaging modalities …

Optical imaging assays, especially fluorescence molecular assays, are minimally invasive if
not completely noninvasive, and thus an ideal technique to be applied to live specimens …

Two-photon fluorescence lifetime imaging microscopy (FLIM) is widely used to capture
autofluorescence signals from cellular components to investigate dynamic physiological …

There is an increasing interest in the application of fluorescence lifetime imaging (FLIM) for
medical diagnosis. Central to the clinical translation of FLIM technology is the development …

Most pathological conditions elicit changes in the tissue optical response that may be
interrogated by one or more optical imaging modalities. Any single modality typically only …

Basal cell carcinoma (BCC) is the most common type of skin cancer. Diagnosis and edge
assessment of BCC lesions are based on clinical and dermoscopy evaluation, which are …

Background: Autofluorescence lifetime (AFL) imaging, a robust technique that enables label-
free molecular investigation of biological tissues, is being introduced into the field of …

We report the design, development, and characterization of a novel multi-spectral
fluorescence lifetime measurement device incorporating solid-state detectors and …