Current challenges of iPSC-based disease modeling and therapeutic implications

MX Doss, A Sachinidis - Cells, 2019 - mdpi.com
Induced pluripotent stem cell (iPSC)-based disease modelling and the cell replacement
therapy approach have proven to be very powerful and instrumental in biomedical research …

Cellular senescence: from mechanisms to current biomarkers and senotherapies

V Lucas, C Cavadas, CA Aveleira, V Hook - Pharmacological Reviews, 2023 - Elsevier
An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …

A comprehensive review for breast histopathology image analysis using classical and deep neural networks

X Zhou, C Li, MM Rahaman, Y Yao, S Ai, C Sun… - IEEE …, 2020 - ieeexplore.ieee.org
Breast cancer is one of the most common and deadliest cancers among women. Since
histopathological images contain sufficient phenotypic information, they play an …

Anti-senescent drug screening by deep learning-based morphology senescence scoring

D Kusumoto, T Seki, H Sawada, A Kunitomi… - Nature …, 2021 - nature.com
Advances in deep learning technology have enabled complex task solutions. The accuracy
of image classification tasks has improved owing to the establishment of convolutional …

The application of convolutional neural network to stem cell biology

D Kusumoto, S Yuasa - Inflammation and regeneration, 2019 - Springer
Induced pluripotent stem cells (iPSC) are one the most prominent innovations of medical
research in the last few decades. iPSCs can be easily generated from human somatic cells …

Single-cell cytometry via multiplexed fluorescence prediction by label-free reflectance microscopy

S Cheng, S Fu, YM Kim, W Song, Y Li, Y Xue, J Yi… - Science …, 2021 - science.org
Traditional imaging cytometry uses fluorescence markers to identify specific structures but is
limited in throughput by the labeling process. We develop a label-free technique that …

Artificial intelligence for microscopy: what you should know

L von Chamier, RF Laine… - Biochemical Society …, 2019 - portlandpress.com
Abstract Artificial Intelligence based on Deep Learning (DL) is opening new horizons in
biomedical research and promises to revolutionize the microscopy field. It is now …

Basic of machine learning and deep learning in imaging for medical physicists

L Manco, N Maffei, S Strolin, S Vichi, L Bottazzi… - Physica Medica, 2021 - Elsevier
The manuscript aims at providing an overview of the published algorithms/automation tool
for artificial intelligence applied to imaging for Healthcare. A PubMed search was performed …

Moving towards induced pluripotent stem cell-based therapies with artificial intelligence and machine learning

C Coronnello, MG Francipane - Stem Cell Reviews and Reports, 2022 - Springer
The advent of induced pluripotent stem cell (iPSC) technology, which allows to transform
one cell type into another, holds the promise to produce therapeutic cells and organs on …

Deep learning neural networks highly predict very early onset of pluripotent stem cell differentiation

A Waisman, A La Greca, AM Möbbs, MA Scarafía… - Stem cell reports, 2019 - cell.com
Deep learning is a significant step forward for developing autonomous tasks. One of its
branches, computer vision, allows image recognition with high accuracy thanks to the use of …