For a study with an event time as the endpoint, its survival function contains all the
information regarding the temporal, stochastic profile of this outcome variable. The survival …

A noninferiority study is often used to investigate whether a treatment's efficacy or safety
profile is acceptable compared with an alternative therapy regarding the time to a clinical …

Background Selective inhibition of cyclo-oxygenase-2 has been associated with an
increased risk of cardiovascular events in several clinical trials. The Adenomatous Polyp …

Background Consider a comparative, randomized clinical study with a specific event time as
the primary end point. In the presence of censoring, standard methods of summarizing the …

Several methods in survival analysis are based on the proportional hazards assumption.
However, this assumption is very restrictive and often not justifiable in practice. Therefore …

Background Providing estimates of uncertainty for statistical quantities is important for
statistical inference. When the statistical quantity of interest is a survival curve, which is a …

In some clinical studies comparing treatments in terms of their survival curves, researchers
may anticipate that the survival curves will cross at some point, leading to interest in a long …

A major biomedical goal associated with evaluating a candidate biomarker or developing a
predictive model score for event-time outcomes is to accurately distinguish between incident …

An accurate measure of allogeneic transplant efficacy should take into account quality-of-life
issues associated with graft-versus-host disease (GVHD). However, unlike death and …

Survival time is the primary endpoint of many randomized controlled trials, and a treatment
effect is typically quantified by the hazard ratio under the assumption of proportional …