Bioinorganic chemistry of Alzheimer's disease

KP Kepp - Chemical reviews, 2012 - ACS Publications
Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

Mercury toxicity and neurodegenerative effects

A Carocci, N Rovito, MS Sinicropi, G Genchi - Reviews of environmental …, 2014 - Springer
Neurodegeneration is a broadly defined term that describes the loss of neuronal structure
and function, and produces disorders known as neurodegenerative diseases. A common …

[HTML][HTML] Decreased brain levels of vitamin B12 in aging, autism and schizophrenia

Y Zhang, NW Hodgson, MS Trivedi, HM Abdolmaleky… - PloS one, 2016 - journals.plos.org
Many studies indicate a crucial role for the vitamin B12 and folate-dependent enzyme
methionine synthase (MS) in brain development and function, but vitamin B12 status in the …

How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis

R Deth, C Muratore, J Benzecry, VA Power-Charnitsky… - Neurotoxicology, 2008 - Elsevier
Recently higher rates of autism diagnosis suggest involvement of environmental factors in
causing this developmental disorder, in concert with genetic risk factors. Autistic children …

Aluminum vaccine adjuvants: are they safe?

L Tomljenovic, CA Shaw - Current medicinal chemistry, 2011 - ingentaconnect.com
Aluminum is an experimentally demonstrated neurotoxin and the most commonly used
vaccine adjuvant. Despite almost 90 years of widespread use of aluminum adjuvants …

Does inorganic mercury play a role in Alzheimer's disease? A systematic review and an integrated molecular mechanism

J Mutter, A Curth, J Naumann, R Deth… - Journal of Alzheimer's …, 2010 - content.iospress.com
Mercury is one of the most toxic substances known to humans. It has been introduced into
the human environment and has also been widely used in medicine. Since circumstantial …

Evidence of toxicity, oxidative stress, and neuronal insult in autism

JK Kern, AM Jones - … of Toxicology and Environmental Health, Part …, 2006 - Taylor & Francis
According to the Autism Society of America, autism is now considered to be an epidemic.
The increase in the rate of autism revealed by epidemiological studies and government …

Early thimerosal exposure and neuropsychological outcomes at 7 to 10 years

WW Thompson, C Price, B Goodson… - … England Journal of …, 2007 - Mass Medical Soc
Background It has been hypothesized that early exposure to thimerosal, a mercury-
containing preservative used in vaccines and immune globulin preparations, is associated …

[HTML][HTML] Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: strategies and challenges

PD Ray, A Yosim, RC Fry - Frontiers in genetics, 2014 - frontiersin.org
Exposure to toxic metals poses a serious human health hazard based on ubiquitous
environmental presence, the extent of exposure, and the toxicity and disease states …

[HTML][HTML] Fragile X and autism: Intertwined at the molecular level leading to targeted treatments

R Hagerman, G Hoem, P Hagerman - Molecular autism, 2010 - Springer
Fragile X syndrome (FXS) is caused by an expanded CGG repeat (> 200 repeats) in the
5'untranslated portion of the fragile mental retardation 1 gene (FMR1), leading to deficiency …