Macrophagic and microglial complexity after neuronal injury

F Mesquida-Veny, JA Del Río, A Hervera - Progress in neurobiology, 2021 - Elsevier
Central nervous system (CNS) injuries do not heal properly in contrast to normal tissue
repair, in which functional recovery typically occurs. The reason for this dichotomy in wound …

[HTML][HTML] Axonal regeneration and sprouting as a potential therapeutic target for nervous system disorders

KL Marshall, MH Farah - Neural Regeneration Research, 2021 - journals.lww.com
Nervous system disorders are prevalent health issues that will only continue to increase in
frequency as the population ages. Dying-back axonopathy is a hallmark of many neurologic …

Advances in current in vitro models on neurodegenerative diseases

I Pereira, MJ Lopez-Martinez, J Samitier - Frontiers in Bioengineering …, 2023 - frontiersin.org
Many neurodegenerative diseases are identified but their causes and cure are far from
being well-known. The problem resides in the complexity of the neural tissue and its location …

HIF-1α Induced by Hypoxia promotes peripheral nerve Injury Recovery through regulating ferroptosis in DRG neuron

S An, J Shi, J Huang, Z Li, M Feng, G Cao - Molecular Neurobiology, 2024 - Springer
Peripheral nerve injury (PNI) usually has a poor effect on functional recovery and severely
declines the patient's quality of life. Our prior findings indicated that hypoxia remarkably …

A brief review of in vitro models for injury and regeneration in the peripheral nervous system

P Varier, G Raju, P Madhusudanan, C Jerard… - International Journal of …, 2022 - mdpi.com
Nerve axonal injury and associated cellular mechanisms leading to peripheral nerve
damage are important topics of research necessary for reducing disability and enhancing …

In vitro modelling of human proprioceptive sensory neurons in the neuromuscular system

M Badiola-Mateos, T Osaki, RD Kamm, J Samitier - Scientific Reports, 2022 - nature.com
Proprioceptive sensory neurons (pSN) are an essential and undervalued part of the
neuromuscular circuit. A protocol to differentiate healthy and amyotrophic lateral sclerosis …

Advances in In Vitro Models of Neuromuscular Junction: Focusing on Organ‐on‐a‐Chip, Organoids, and Biohybrid Robotics

Y Leng, X Li, F Zheng, H Liu, C Wang… - Advanced …, 2023 - Wiley Online Library
The neuromuscular junction (NMJ) is a peripheral synaptic connection between presynaptic
motor neurons and postsynaptic skeletal muscle fibers that enables muscle contraction and …

Assessment of corneal nerve regeneration after axotomy in a compartmentalized microfluidic chip model with automated 3D high resolution live-imaging

N Bonneau, A Potey, F Blond, C Guerin… - Frontiers in Cellular …, 2024 - frontiersin.org
Introduction Damage to the corneal nerves can result in discomfort and chronic pain,
profoundly impacting the quality of life of patients. Development of novel in vitro method is …

Advances in nerve injury models on a Chip

D Lee, K Yang, J Xie - Advanced Biology, 2023 - Wiley Online Library
Regeneration and functional recovery of the damaged nerve are challenging due to the
need for effective therapeutic drugs, biomaterials, and approaches. The poor outcome of the …

Development of a simple and versatile in vitro method for production, stimulation, and analysis of bioengineered muscle

K Wells-Cembrano, J Sala-Jarque, JA Del Rio - PLoS One, 2022 - journals.plos.org
In recent years, 3D in vitro modeling of human skeletal muscle has emerged as a subject of
increasing interest, due to its applicability in basic studies or screening platforms. These …