Structural and functional defects within the lungs of children with cystic fibrosis (CF) are
detectable soon after birth and progress throughout preschool years often without overt …

Cystic fibrosis (CF) is the most common inherited disease in Caucasian populations,
affecting around 50,000 patients in Europe and 30,000 in United States. A mutation in CF …

Rationale: The lung clearance index (LCI) is responsive to acute respiratory events in
preschool children with cystic fibrosis (CF), but its utility to identify and manage these events …

Pulmonary magnetic resonance imaging using hyperpolarised 129Xe gas (XeMRI) can
quantify ventilation inhomogeneity by measuring the percentage of unventilated lung …

Background Antibiotic treatment for pulmonary symptoms in preschool children with cystic
fibrosis (CF) varies among clinicians. The lung clearance index (LCI) is sensitive to early CF …

The lung clearance index (LCI) measured by the multiple breath washout (MBW) test is
sensitive to early lung disease in children with cystic fibrosis. While LCI worsens during the …

Background New drugs that target the basic defect in cystic fibrosis (CF) patients may now
be used in a large number of patients carrying responsive mutations. Nevertheless, further …

Introduction Xenon-129 (129Xe) ventilation magnetic resonance imaging (MRI) is sensitive
to detect early cystic fibrosis (CF) lung disease and response to treatment. 129Xe-MRI could …

Background Chronic lung diseases such as cystic fibrosis (CF) can be monitored by imaging
and lung function modalities. Magnetic resonance imaging (MRI) techniques such as matrix …

The past decade has been one of rapid advance for Multiple Breath Washout (MBW) as a
tool to detect early obstructive lung disease. Consensus recommendations for both …