Regeneration is the process by which organisms replace lost or damaged tissue, and
regenerative capacity can vary greatly among species, tissues and life stages. Tissue …

Cancer is a systemic disease that involves malignant cell-intrinsic and-extrinsic metabolic
adaptations. Most studies have tended to focus on elucidating the metabolic vulnerabilities …

Adult liver has enormous regenerative capacity; it can regenerate after losing two-thirds of its
mass while sustaining essential metabolic functions. How the liver balances dual demands …

Identifying new pathways that regulate mammalian regeneration is challenging due to the
paucity of in vivo screening approaches. We employed pooled CRISPR knockout and …

Mitochondria dysfunction contributes to acute liver injuries, and mitochondrial regulators,
such as PGC-1α and MCJ, affect liver regeneration. Therefore, identification of mitochondrial …

The adult liver has an exceptional ability to regenerate, but how it maintains its specialized
functions during regeneration is unclear. Here, we used partial hepatectomy (PHx) in …

Disruption of cell division cycle associated 7 (CDCA7) has been linked to aberrant DNA
hypomethylation, but the impact of DNA methylation loss on transcription has not been …

Cancer stem cells (CSCs) contribute to tumor initiation, progression, and recurrence in many
types of cancer, including hepatocellular carcinoma (HCC). Epigenetic reprogramming of …

Background Loss-of-function mutations or abnormal expressions of E ubiquitin ligases
contributes to tumorigenesis. TRIM38 was reported to regulate immunity, inflammatory …

Following injury, the liver's epithelial cells regenerate efficiently with rapid proliferation of
hepatocytes and biliary cells. However, when proliferation of resident epithelial cells is …