Overexpression of the human epidermal growth factor-2 (HER2) oncogene in human breast
carcinomas has been associated with a more aggressive course of disease. The reason for …

Publisher Summary Carcinoma, cancer of epithelial cells, is a major cause of morbidity and
mortality. Clonal fixation and propagation of oncogenic genetic changes, sporadically …

Exosomes are a valuable biomaterial for the development of novel nanocarriers as
functionally advanced drug delivery systems. To control and modify the performance of …

Abstract The OX-40 receptor (OX-40R), a member of the TNFR family, is primarily expressed
on activated CD4+ T lymphocytes. Engagement of the OX-40R, with either OX-40 ligand (OX …

Despite tremendous progress in basic and epidemiological research, effective prevention of
most types of cancer is still lacking. Vaccine use in cancer therapy remains a promising but …

Early-phase clinical trials evaluating CD8+ T cell–eliciting, HER2-derived peptide vaccines
administered to HER2+ breast cancer patients in the adjuvant setting suggest synergy …

The ability of vaccination with plasmids coding for the extracellular and the transmembrane
domain of the product of transforming rat Her-2/neu oncogene (r-p185) to protect against r …

Abstract Overexpression of HER-2/neu (c-erbB2) is associated with increased risk of
recurrent disease in ductal carcinoma in situ (DCIS) and a poorer prognosis in node-positive …

The product of the Wilms' tumor gene WT1 is a transcription factor overexpressed not only in
leukemic blast cells of almost all patients with acute myeloid leukemia, acute lymphoid …

For over a century, inactivated or attenuated bacteria have been employed in the clinic as
immunotherapies to treat cancer, starting with the Coley's vaccines in the 19th century and …