The concept that different systems control episodic and surge secretion of gonadotropin‐
releasing hormone (GnRH) was well established by the time that GnRH was identified and …

In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were first identified
in the mammalian hypothalamus, a plethora of new research has emerged adding insights …

The mechanisms underlying the homeostatic estrogen negative feedback pathway central to
mammalian fertility have remained unresolved. Direct measurement of gonadotropin …

Neurons in the hypothalamic arcuate nucleus (ARC) that co-express kisspeptin, neurokinin
B and dynorphin (KNDy cells) are essential for mammalian reproduction as key regulators of …

BACKGROUND Puberty is a complex developmental event, controlled by sophisticated
regulatory networks that integrate peripheral and internal cues and impinge at the brain …

Central estrogen signaling coordinates energy expenditure, reproduction, and in concert
with peripheral estrogen impacts skeletal homeostasis in females. Here, we ablate estrogen …

Mammalian reproductive function includes puberty onset and completion, reproductive
cyclicity, steroidogenesis, gametogenesis, fertilization, pregnancy, and lactation; all are …

The brain regulates fertility through gonadotropin-releasing hormone (GnRH) neurons.
Estradiol induces negative feedback on pulsatile GnRH/luteinizing hormone (LH) release …

Synchronization of mammalian breeding activity to the annual change of photoperiod and
environmental conditions is of the utmost importance for individual survival and species …

Estradiol feedback regulates gonadotropin-releasing hormone (GnRH) neurons and
subsequent luteinizing hormone (LH) release. Estradiol acts via estrogen receptor α (ERα) …