ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …

Cells acquire their ultimate identities by activating combinations of transcription factors that
initiate and sustain expression of the appropriate cell type-specific genes. T cell …

T cell development in the mouse thymus has been studied extensively, but less is known
regarding T cell development in the human thymus. We used a combination of single-cell …

T cells are the key mediators in cell-mediated immunity. Their development and maturation
involve a complex variety of interactions with nonlymphoid cell products and receptors …

The differentiation of αβT cells from thymic precursors is a complex process essential for
adaptive immunity. Here we exploited the breadth of expression data sets from the …

Multipotent blood progenitor cells enter the thymus and begin a protracted differentiation
process in which they gradually acquire T-cell characteristics while shedding their legacy of …

The cellular differentiation pathway originating from the bone marrow leading to early T
lymphocytes remains poorly understood. The view that T cells branch off from a lymphoid …

T and B cells share a common somatic gene rearrangement mechanism for assembling the
genes that code for their antigen receptors; they also have developmental pathways with …

T lymphopoiesis requires settling of the thymus by bone marrow–derived precursors
throughout adult life. Progenitor entry into the thymus is selective, but the molecular basis of …

Although transcriptional programs associated with T-cell specification and commitment have
been described, the functional hierarchy and the roles of key regulators in structuring …