Cohesin mediates chromatin loop formation across the genome by extruding chromatin
between convergently oriented CTCF-binding elements. Recent studies indicate that …

Simple Summary Multiple myeloma is an incurable blood cancer caused by the malignant
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …

Immunoglobulin heavy chain variable region exons are assembled in progenitor-B cells,
from VH, D, and JH gene segments located in separate clusters across the Igh locus. RAG …

SHLD1 is part of the Shieldin (SHLD) complex, which acts downstream of 53BP1 to
counteract DNA double-strand break (DSB) end resection and promote DNA repair via non …

Class switch recombination (CSR) diversifies the effector functions of antibodies and
involves complex regulation of transcription and DNA damage repair. Here, we show that …

We developed a linear amplification–mediated high-throughput genome-wide translocation
sequencing method to profile Ig class-switch recombination (CSR) in human B cells in an …

Activation-induced cytidine deaminase (AID) initiates somatic hypermutation of
immunoglobulin (Ig) gene variable regions and class switch recombination (CSR) of Ig …

B cells undergo genetic rearrangements at immunoglobulin gene (Ig) loci during B cell
maturation. First V (D) J recombination occurs during early B cell stages followed by class …

RNA processing includes post-transcriptional mechanisms controlling RNA quality and
quantity to ensure cellular homeostasis. Noncoding (nc) RNAs that are regulated by these …

In B lymphocytes, class switch recombination (CSR) is an essential process that adapts
immunoglobulin (Ig) subtypes to antigen response. Taking place within the Ig heavy chain …