Highlights•Synthetic biology aims to apply engineering principles in biology.•Insufficient part
libraries, standards, and software are challenges to the field.•Working on the challenges will …

This special issue of the Journal of Integrative Bioinformatics contains updated
specifications of COMBINE standards in systems and synthetic biology. The 2022 special …

CRISPR/Cas ability to target several loci simultaneously (multiplexing) is a game-changer in
plant breeding. Multiplexing not only accelerates trait pyramiding but also can unveil traits …

As genetic circuits become more sophisticated, the size and complexity of data about their
designs increase. The data captured goes beyond genetic sequences alone; information …

Synthetic biology research has led to the development of many software tools for designing,
constructing, editing, simulating, and sharing genetic parts and circuits. Among these tools …

Standards shape our everyday life. From nuts and bolts to electronic devices and
technological processes, standardised products and processes are all around us. Standards …

In synthetic biology, combinational circuits are used to program cells for various new
applications like biosensors, drug delivery systems, and biofuels. Similar to asynchronous …

Engineering genetic regulatory circuits is key to the creation of biological applications that
are responsive to environmental changes. Computational models can assist in …

The “COmputational Modeling in BIology NEtwork”(COMBINE) initiative aims to harmonise
the development of diverse community standards for computational models in biology [1, 2] …

This special issue of the Journal of Integrative Bioinformatics contains updated
specifications of COMBINE standards in systems and synthetic biology. The 2021 special …